Palmitoylethanolamide(PEA)isabio-identicalfattyacidamide thatIsnormallysynthesizedbyhealthytissueInthehumanbody inresponsetoinflammation.PEAismadebyvariousplantsand animalsandispresentthroughouttheanimalkingdom.PEAcan befoundinmanydifferenttissuesincludingglia,neurons,retina, white blood cells, mast cells and adipocytes.
Supplementing withPEAhasbeensclentlffcallyshowntonaturallyassistinthereduction ofinflammationandtohaveneuro-protectiveandpossiblypain controleffects.Thisnaturalanti-inflammatorysupportsthenervous system and abnormal immuneresponses.*
Palmitoylethanolamide (PEA) – backed by more than 300+ medical studies, has been shown to be or assist with:
Natural Pain Reliever
Neuroprotective at the cellular level
Pain and nervous system conditions
Muscle recovery and muscle pain
Immune system support
What are Glial and Mast Cells? Glial cells are various types of companion cells in the central and peripheral nervous system. Once thought to be nothing more than the glue that holds the brain together, these cells are now understood to have a much more complex role in the brain besides simply acting as a scaffold. Glial cells are responsible for nourishing neurons, facilitating nerve impulses, and exerting an inflammatory response on neurons.Dysregulation and over-activation of glial cells can have a detrimental effect on the nervous system[6,7,8].
Mast cells are a type of immune system cell that responds to chemical signals from tissue injury. When mast cells “degranulate,” they release a payload of inflammatory cytokines, NGF, histamines, and other molecules in the surrounding tissue. These chemicals attract white blood cells and activate their immune response against pathogens. Mast cells also activate nociceptors (pain receptors) with the chemicals they secrete.
How does it work? Palmitoylethanolamide is thought to act primarily on the Peroxisome Proliferator Activated Receptor Alpha (PPAR-α), a receptor in the cell nucleus. It also has affinity for the cannabinoid-like G-coupled receptors GPR55 and GPR119, although it has no affinity for the classical cannabinoid receptors CB1 and CB2. This is why it is sometimes referred to as a non-psychoactive “indirect endocannabinoid.”
It does not block pain signals the way opioids and other analgestics do. Instead it works upstream by supporting the healthy function of glial cells and mast cells.*
Pro GAD Enhancer, created by a leading neuro-immune specialist, was created to assist patients who have difficulty producing adequate amounts of GABA, an important brain neurotransmitter. GABA plays the principal role of reducing excitability throughout the nervous system, as well as, regulation of musde relaxation. Many patients possess a genetic mutation of GAD (Glutamic Acid Decarboxylase), the primary enzyme that creates GABA. A weakness in the GAD enzyme creates an increased amount of Glutamate, the primary excitatory neurotransmitter of the nervous system, and a relative deficiency of GABA. This imbalance creates an overly stimulated nervous system.
The 5 key ingredients are designed to assist with:
Neuro Night Essentials, created by
our advising physicians, is a proprietary blend of
specifically designed to promote healthy sleep, support the body’s normal
nocturnal rhythms during stress, and help those who may have occasional
Overview: Sleep is the body's way of metabolically and psychologically resetting itself for the next day. The body's circadian rhythm is regulated by an internal biological clock. In order to maintain quality and restorative sleep, it is crucial that the brain has optimal levels of serotonin and gamma-amino butyric acid (GABA), the relaxing sleep regulating neurotransmitters, as well as the sleep regulating hormone melatonin. The combination of the ingredients in Neuro Night Essentials will help naturally boost levels of neurotransmitters that promote relaxation prior to bedtime and promote deep and complete stages of sleep.
GABA: Gamma-amino butyric acid (GABA) is one of the major inhibitory neurotransmitters in the brain. GABA provides a calming effect and plays a direct role in serotonin synthesis.
Melatonin: Is a natural hormone in each one of us that is produced in our pineal gland. It effects the sleep and wake cycle and should peak at night. Sometimes, due to stress, hormone imbalance, illness, or other issues, that cycle can be disrupted. Melatonin gets you back on track. It is quickly metabolized, allowing you to have quick and effective results.
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*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnosis, treat, cure or prevent any disease.